keikop2

This retrospective study incorporates computational fluid dynamics (CFD), computed tomography angiograms (CTA), and Transcranial Doppler (TCD) wave forms obtained from patients presenting with subarachnoid hemorrhage (SAH) and vasospasm. CTA images taken prior to balloon angioplasty treatment of vasospasm are analyzed using computer simulations. Using this data, we hope to develop an effective model for predicting the likelihood of vasospasm and its location in SAH patients.

In this National Institute on Aging (NIA) funded R03 project we are developing a method for whole brain mechanical simulation of the flow of cerebrospinal fluid. By incorporating patient specific tissue displacement measurements from state-of-the-art MRI techniques we can calculate maps of tissue stiffness and CSF flux to study how these mechanical aspects of brain function are altered during the development of Alzheimer’s Disease. This tool when fully implemented will be useful for...

Our National Institute of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) R01 funded project titled Computational modeling of platelets and thrombosis in cerebral aneurysm treatment seeks to develop hemodynamic risk factors for aneurysm recurrence after treatment through developing a clinically applicable modeling toolkit based on novel simulation methods through investigating the pre and post treatment hemodynamics of adult patients undergoing coil or stent- coil...